Center of Regenerative Medicine


News & Events



Mayssa Mokalled PhD joins the CRM and the Department of Developmental Biology, beginning August 1. The Mokalled Lab will study spinal cord regeneration in zebrafish. Welcome Mayssa!



Congratulations to Co-Director Lila Solnica-Krezel on being elected President of the Society for Developmental Biology for 2018-2019.





• August 9: Nanofabrication Info Session | Mid Campus Center, Room 2057 @noon

• August 29: Regeneration, Aging, & Development Journal Club | Needleman Library @ 9am

• September 25: Lawrence Lum PhD | Needleman Library @ noon

• October 17: CRM Faculty Retreat | 4240 Building @ 12:30pm


Recent Publications

• Click here for 2014 Publications


• Click here for 2015 Publications


• Click here for 2016 Publications


p53 mediates failure of human definitive hematopoiesis in dyskeratosis congenital.  Fok WC, Niero EL, Dege C, Brenner KA, Sturgeon CM, & Batista LFZ. Stem Cell Rep. 2017.

Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4.  Philip Creamer J, Sturgeon CM, et al. Blood 129:2988-2992, 2017.

The SARM1 Toll/Interleukin-1 receptor domain possesses intrinsic NAD+ cleavage activity that promotes pathological axon degeneration.  Essman K, DiAntonio A, & Milbrandt J, et al. Neuron 93:1334-1343, 2017.

Therapeutic efficacy of intra-articular hyaluronan derivative and platelet-rich plasma in mice following axial tibial loading. Duan X, Sandell LJ, Chinzei N, Holguin N, Silva MJ, Schiavinato A, Rai MF. PLoS ONE 12:e0175682, 2017.


Adventitial MSC-like cells are progenitors of vascular smooth muscle cells and drive vascular calcification in chronic kidney disease. Kramann R, Jain S, & Humphreys BD et al. Cell Stem Cell 19:628-42, 2016.


Human organotypic cultured cardiac slices: new platform for high throughput preclinical human trials.  Kang C, Qiao Y, Li G, Baechle K, Carmelliti P, Rentschler S, Efimov IR. Sci. Rep. 6:28798, 2016.

Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation.  Bijerk R, Humphreys BD, van Zonneveld AJ et al. Kidney Intl. 89:1268-80, 2016.

Reprogrammable CRISPR/Cas9-based system for inducing site specific DNA methylation.  McDonald JI & Challen GA et al. Biol. Open 5:866-74, 2016.

Cartilage-specific knockout of the mechanosensory ion channel TRPV4 decreases age-related osteoarthritis.  O’Connor CJ & Guilak F et al. Sci. Rep. 6:29053, 2016.

Antisense oligonucleotides for amyotrophic lateral sclerosis.  Self WK & Miller TM. Trans. Neurosci: Fundamental Approaches for Neurological Disorders 99-109, 2016.

Cutting to the chase: taking the pulse of label-retaining cells in kidney.  Humphreys BD. Am. J. Phys Renal Phys. 308:F29-30, 2016.

3D Printing: 3D printing of highly stretchable and tough hydrogels into complex cellularized structures.  Hong S, Guilak F, Leong KW, Zhao X et al. Ad. Materials 27:4034, 2016.

Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure.  Sager HB, Hulsmans M, Lavine KJ, and Nahrendorf et al. Circ. Res. 2016.

Germline stem cell differentiation entails regional control of cell fate regulator GLD-1 in Caenorhabditis elegans. Brenner JL & Schedl T. Genetics 202:1085-1103, 2016.

Signaling cascades governing Cdc42-mediated chrondrogenic differentiation and mesenchymal condensation. Wang J, Long F, & Wu X et al. Genetics 203:1055-69, 2016.

Adhesion G protein-coupled receptors in nervous system development and disease. Langerhan T, Piao X, & Monk KR. Nat. Rev. Neurosci, 2016.

Direct lineage reprogramming via pioneer factors: a detour through developmental gene regulatory networks. Morris SA. Development 143:2696-705, 2016.

Modeling zika virus infection in pregnancy. Mysorekar IU & Diamond MS. NEJM 375:481-4, 2016.

Impaired autophagy in macrophages promotes inflammatory eye diseases. Santeford A & Apte RS et al. Autophagy 1-10, 2016.

Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity. Pan Y, Wang T, Kim AH, & Yano H et al. Sci. Rep. 6:31022, 2016.

ZBTB32 restricts the duration of memory B cell recall responses.  Jash A & Bhattacharya D et al. J. Immunol. 197:1159-68, 2016.

ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors.  Becker AM, Walcheck B, & Bhattacharya D. Exp. Hematol. 43:44-52, 2016.

Hepatocyte nuclear factor 4 is required for cell differentiation and homeostasis in the adult mouse gastric epithelium.  Moore BD & Mills JC et al. Am. J. Phys. Gastroint. Liver Phys. 311:G267-75, 2016.

Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.  Uchiyama K, Stappenbeck T, & Chang EB et al. Sci. Rep. 6:32094, 2016.

Increased glutamine catabolism mediates bone anabolism in response to WNT signaling. Karner CM & Long F et al. J. Clin. Invest. 125:551-62, 2016.

Clonal haematopoiesis harboring AML-associated mutations is ubiquitous in healthy adults.  Young AL, Challen GA, Birmann BM, & Druley TE. Nat. Comm. 7:12484, 2016.

Schwann cell O-GlcNAc glycosylation is required for myelin maintenance and axon integrity. Kim S & Milbrandt J et al. J. Neurosci. 36:9633-46, 2016.

Activation of Wnt signaling by mechanical loading is impaired in the bone of old mice.  Holguin N, Brodt MD, & Silva MJ. J. Bone Min. Res., 2016.

Axonal growth arrests after an increased accumulation of schwann cells expressing senescence markers and stromal cells in acellular nerve allografts. Poppler LH, Mackinnon SE, & Wood MD et al. Tissue Engineering – Part A. 22:949-61, 2016.

Early changes in the knee of healer and non-healer mice following non-invasive mechanical injury. Duan X, Rai MF, Silva MJ, & Sandell LJ et al. J. Ortho Res., 2016.

Inflammatory signals in HSPC development and homeostasis: too much of a good thing? Luis TC & Challen GA et al. Exp. Hematol. 44:908-12, 2016.

Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation.  Kanekura K, Miller TM, & Urano F et al. Hum. Mol. Genet. 25:1803-13, 2016.

Mitochondrial pyruvate import promotes long-term survival of antibody-secreting plasma cells.  Lam WY & Bhattacharya D et al. Immunity 45:60-73, 2016.

Suppression of NF-kB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.  Yan H, Rai MF, Sandell LJ, & Pham CTN et al. PNAS 113:E6199-208, 2016.

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion. Sasaki Y, DiAntonio A, & Milbrandt J et al. eLife 5:e19749, 2016.

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation. Summers DW, Gibson DA, DiAntonio A, & Milbrandt J. PNAS 113:E6271-80, 2016.


Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses.  Jacobs KM & Sharma GG et al. Mol. Biol. Cell 27: 1332-45, 2016.

Evolution of epigenetic regulation in vertebrate genomes.  Lowdon RF, Jang HS, & Wang T. Trends Genet. 35:269-83, 2016.

Proline Absorption and SGK1 Expression are Inhibited in Intestinal Tis7 Transgenic Mice.  Lu J and Rubin DC et al. Cell Phys. Biochem. 1532-43, 2016.

CRALBP supports the mammalian retinal visual cycle and cone vision. Xue Y, Corbo JC, & Kefalov VJ et al. J Clin. Invest. 125: 727-38, 2016.

Mapping of variable DNA methylation across multiple cell types defines a dynamic regulatory landscape of the human genome. Gu J & Wang T et al. G3: Genes, Genomes, Genetics 6: 973-86, 2016.

Developmental biology and regenerative medicine: Addressing the vexing problem of persistent muscle atrophy in the chronically torn human rotator cuff. Meyer GA & Ward SR. Phys. Ther. 96: 722-33, 2016.

Directed differentiation of definitive hemogenic endothelium and hematopoietic progenitors from human pluripotent stem cells. Ditadi A & Sturgeon CM. Methods 101:65-72, 2016.

Intracellular Golgi Complex organization reveals tissue specific polarity during zebrafish embryogenesis. Sepich DS & Solnica-Krezel L. Dev. Dyn., 2016.

Transcriptional regulation of X-Box-binding protein One (XBP1) by hepatocyte nuclear factor 4- (HNF4-) is vital to beta-cell function. Moore BD, Urano F, & Mills JC et al. J. Biol. Chem. 291: 6146-57, 2016.

TMEM184b promotes axon degeneration and neuromuscular junction maintenance. Bhattacharya MRC, Milbrandt J, & DiAntonio A et al. J. Neurosci. 36: 4681-89, 2016.

Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody. Yin Y & Ornitz DM et al. Dis. Models. Mech. 9: 563-71, 2016.

Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Miner JJ, Mysorekar IU, & Diamond MS et al. Cell, 2016.

Fabrication of anatomically-shaped cartilage constructs using decellularized cartilage-derived matrix scaffolds. Rowland CR, Colucci LA, & Guilak F. Biomaterials 91:57-72, 2016.

FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth. Karuppaiah K, Long F, & Ornitz DM et al. Development 143:1811-22, 2016.

Vascularization is delayed in long nerve constructs compared with nerve grafts. Farber SJ, Mackinnon SE, & Wood MD et al. Muscle and Nerve, 2016

Developing novel diabetes treatments targeting the endoplasmic reticulum-wolfram syndrome as an ideal model. Urano F. J. Japan. Diabetes Soc. 59:340-3, 2016.

Defining SOD1 ALS natural history to guide therapeutic clinical trial design. Bali T & Miller TM et al. J Neurol. Neurosurg. Psych., 2016.

Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. Kanju P, Guilak F, & Liedtke WB et al. Sci. Rep. 6:26894, 2016.

N-cadherin is key to expression of the nucleus pulposus cell phenotype under selective substrate culture conditions. Hwang PY, Guilak F & Setton LA et al. Sci. Rep. 6:28038.

An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK. Hao Y, DiAntonio A, & Collins C et al. eLife 5:14048, 2016.

Combinatorial strategies based on CRAd-IL24 and CRAd-ING4 virotherapy with anti-angiogenesis treatment for ovarian cancer. Ashshi AM & Curiel DT et al. J. Ovar. Res. 9:38, 2016.


Generation of highly enriched V2a interneurons from mouse embryonic stem cells. Iyer NR, Huettner JE, Butts JC, Brown CR, and Sakiyama-Elbert SEExperimental Neurology 277:305-16, 2016.

Stromal-initiated changes in the bone promote metastatic niche development. Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA. Cell Reports 14:82-92, 2016.

Wolfram Syndrome: diagnosis, management, and treatment. Urano F. Curr Diabetes Rep. 16:1-8, 2016.

Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer. Santhanam S, Alvarado DM, Ciorba MA. Translational Res 167:67-79, 2016.

Distinct firing properties of vasoactive intestinal peptide-expressing neurons in the suprachiasmatic nucleus. Hermanstyne TO, Simms CL, Carrasquillo Y, Herzog ED, Nerbonne JM. J Biol Rhythms 31:57-67, 2016.

Cell migration and invadopodia formation require a membrane-binding domain of CARMIL2. Lanier MH, McConnell P, Cooper JAJBC 291:1076-91, 2016.

Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse.Lim J, Shi Y, Karner CM, Lee S-Y, Lee W-C, He G. Long FDevelopment 143:339-47, 2016.

An engineering biocompatible drug delivery system enhances nerve regeneration after delayed repair. Tajdaran K, Gordon T, Wood MD, Shoichet MS, Borschel GH. J Biomed Mat Res – Part A 104:367-76, 2016.

Development and use of an animal model to study post-traumatic stiffness and contracture of the elbow. Lake SP, Castile RM, Borinsky S, Dunahm CL, Havlioglu N, Galatz LM. J Orthopaedic Res 34:354-64, 2016.

A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development. Hung IH, Schoenwolf GC, Lewandowski M, Ornitz DM. Dev Biol, 2016.

Massively-parallel cis-regulatory analysis in the mammalian central nervous system.Shen SQ, Myers CA, Hughes AEO, Byrne LC, Flannery JG, Corbo JCGenome Res 26:238-55, 2016.

The effect of short nerve grafts in series on axonal regeneration across isografts or acellular nerve allografts. Yan Y, Wood MD, Hunter DA, Ee X, Mackinnon SE, Moore AM. J Hand Surgery, 2016.

Targeting tissue lipids in age-related macular degeneration. Apte RS. EBioMedicine, 2016.

Signaling over distances. Saito A and Cavalli V. Mol and Cell Proteomics 15:282-393, 2016.

Microstructural properties and mechanics vary between bundles of the human anterior cruciate ligament during stress-relaxation. Castile RM, Skelley NW, Babaei B, Brophy RH, Lake SP. J Biomechanics 49:87-93, 2016.

Reprogramming the conduction system: onward toward a biological pacemaker.Meyers JD, Jay PY, Rentschler S. Trends Cardiovascular Med 26:14-20, 2016.

Axon self-destruction: new links among SARM1, MAPKs, and NAD+ metabolism. Gerdts J, Summers DW, Milbrandt J, DiAntonio A. Neuron 89:449-60, 2016.

In vivo luminescent imaging of NF-kB activity and NF-kB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy. Bowles RD, Karikari IO, Vanderwerken DN, Sinclair MS, Bell RD, Riebe KJ, Huebner JL, Kraus VB, Sempowski GD, Setton LA. E J Pain 20:365-76, 2016.

Notch activation associated with poor outcomes in heart failure: is it harmful, or not enough of a good thing? Chipalunkar A and Rentschler S. J Cardiac Failure 22:224-5, 2016.

Postponing the hypoglycemic response to partial hepatectomy delays mouse liver regeneration. Huang J, Schriefer AE, Clifton PF, Dietzen D, Kulkami S, Sing S, Monga SPS, Rudnick DA. A J Pathol 186:587-99, 2016.

Paracrine wnt1 drives interstitial fibrosis without inflammation by tubulointerstitial cross-talk. Maarouf OH, Aravamudhan A, Rangaragan D, Kusaba T, Zhang V, Welborn J, Gauvin D, Hou X, Kramann R, Humphreys BD. J Am Soc Nephrology 27:781-90, 2016.

DNA methylation in normal and malignant hematopoiesis. Celik H, Kramer A, Challen GA. I J Hematol 1-10, 2016.

Alzheimer’s disease risk polymorphisms regulate gene expression in the ZCWPW1 and CELF1 loci. Karch CM et al. PLoS ONE 11:e0148717.

Primitive embryonic macrophages are required for coronary development and maturation. Leid J, Carrelha J, Boukarabila H, Epelman S, Jacobsen SE, Lavine KJ. Cir Res, 2016.

Pulmonary vasculature directed adenovirus increases epithelial lining fluid alpha-1 antitrypsin levels. Buggio M, Towe C, Annan A, Kaliberov S, Lu S, Stephens ZH, Arbeit JM, Curiel DT. J Gene Med 18:38-44, 2016.

Models of axon regeneration in Drosophila. Brace EJ and DiAntonio A. Exp Neurol, 2016.

Universally conserved relationships between nuclear shape and cytoplasmic mechanical properties in human stem cells. Lozoya OA, Gilchrist CL Guilak F. Scientific Rep 6:23047, 2016.

An engineered biocompatible drug delivery system enhances nerve regeneration after delayed repair.  Tajdaran K, Gordon T, Wood MD, Shoichet MS, Borschel GH.  J Biomed Mat Res – A, 2016.

Tissue constructs: platforms for basic research and drug discovery.  Elson EL and Genin GM.  Interface Focus 6:2015009519, 2016.

Modeling approaches for evaluating multiscale tendon mechanics.  Fang F and Lake SPInterface Focus 6:2015004413, 2016.