Eugene Johnson, Ph.D.
Departments of Developmental Biology and Neurology
The major focus is on the biological function and pharmacological and clinical potential of GFL neurotrophic factors. Three members of that family (neurturin, persephin, and artemin) were discovered in a collaboration of the Johnson lab and the lab of Dr. Jeffrey Milbrandt.
- L. H. Wang, A. J. Paden, and E. M. Johnson, Jr., "Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival,"J. Pharmacol. Exp. Ther., 312, 1007-1019 (2005).
- M. L. Leitner, L. H. Wang, P. A. Osborne, J. P. Golden, J. Milbrandt, and E. M. Johnson, Jr., "Expression and function of GDNF ligands and receptors in the carotid body." Exp. Neurol., 191, S68-S79 (2005).
- C. G. Besirli, E. F. Wagner, and E. M. Johnson, Jr., "The limited role of N-terminal c-Jun phosphorylation in neuronal apoptosis: Identification of the Nuclear Pore Complex as a potential target of the JNK pathway." J. Cell Biol., 170, 401-411 (2005).
- M. Encinas, R. J. Crowder, J. Milbrandt, and E. M. Johnson, Jr., "Tyrosine 981, a novel Ret autophosphorylation site, binds c-Src to mediate neuronal survival," J. Biol. Chem,, 279, 18262-18269 (2004).
- B. A Pierchala, R. C. Ahrens, A. J. Paden, and E. M. Johnson, Jr., "NGF promotes the survival of sympathetic neurons through the cooperative function of the PKC and PI-3-K pathways," J. Biol Chem, 279, 27986-27993 (2004).
- S. Jain, C. K. Naughton, M. Yang, A. Strickland, K. Vij, M. Encinas, J. Golden, A. Gupta, R. Heuckeroth, E. M. Johnson, Jr., and J. Milbrandt, "Mice expressing a dominant negative Ret mutation phenocopy Hirschsprung disease and delineate a role of Ret in spermatogenesis," Development, 131, 5503-5513 (2004).
- H. Enomoto, I. Hughes, J. P. Golden, R. H. Baloh, S. Yonemura, R. O. Heuckeroth, E. M. Johnson, Jr., and J. Milbrandt, "GFRα1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration," Neuron, 44, 623-636 (2004).
- L. H. Wang, C. G. Besirli, and E. M. Johnson, Jr., "Mixed Lineage Kinases: A target for prevention of neurodegeneration," Ann Rev. Pharmacol. Toxicol, 44, 451-474 (2004)
- B.S. in Pharmacy and Ph.D in Medicinal Chemistry- University of Maryland
- Postdoctoral Training in Pharmacology - Washington University
- Associate Director Alzheimer's Disease Research Center
- Member of the Scientific Advisory Board of the Michael J. Fox Foundation
- Member of the AT Children's Project
- Member of the Advisory Council of the National Institute on Aging.
- Serves on the Editorial Boards of Neuron and Neurobiology of Disease
- Serves as Section Editor for Experimental Neurology and Neurobiology of Aging.
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Nerve stepping stone has minimal impact in aiding regeneration across long acellular nerve allografts. Yan Y, Hunter DA, Schellhardt L, Ee X, Snyder-Warwick AK, Moore…