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Washington University in St. Louis - School of Medicine
Department of Developmental Biology

Gregory A. Grant, Ph.D.

Professor and PNACL Director

Washington University School of Medicine
Campus Box 8103
660 South Euclid Avenue
St. Louis , MO 63110
(314) 362-3367

Links

Research Interests

The main focus of the laboratory deals with the structural basis of allosteric control and its long term application to understanding control processes resulting from protein-ligand and protein-protein interactions. This research focuses on specific structural domains found in a wide variety of metabolic proteins and transcription regulators, the ACT and ASB domains, that interact with small molecules to affect the activity of the protein. Major techniques utilized will be, site-directed mutagenesis, transient kinetic analysis, fluorescence techniques, and x-ray crystallography. These studies are an integral step in the long term goals of this laboratory to determine the relationship between structure and function in conformationally regulated control mechanisms, to eventually relate that to the physiology and pathophysiology mediated by these enzymes and by analogous systems, and to eventually understand allosteric proteins well enough to be able to apply basic principles to more complex systems.

Selected Publications

 

For a complete list of Dr. Grant's publications, click here

Gregory A. Grant, Ph.D.

Professor and PNACL Director

Washington University School of Medicine
Campus Box 8103
660 South Euclid Avenue
St. Louis , MO 63110
(314) 362-3367

Links

Other Information

Training

  • 1971: Iowa State University, Ames, IA. B.S. Biochemistry
  • 1975: University of Wisconsin, Madison, WI. Ph.D. Biochemistry
  • 1975-78: Washington University, St. Louis, MO. Post-Doc. Protein Chemistry

Academic Positions (all at Washington University)

  • Sept.'78-June'80: Research Asst. Prof. of Biochemistry in Medicine, Department of Medicine (Dermatology)
  • July '80-Aug.'82: Research Asst. Prof. of Biochemistry in Medicine and Biological Chemistry, Department of Medicine (Dermatology) and Department of Biological Chemistry
  • Sept.'82-Dec.'88: Assistant Professor of Biological Chemistry, and of Biochemistry in Medicine, Department of Biological Chemistry and Department of Medicine (Dermatology)
  • Sept.'82-Present: Director, Protein Chemistry Laboratory
  • Jan. '89-Dec.'91: Associate Professor, Department of Biochemistry and Molecular Biophysics, and Department of Medicine
  • Jan.'92-June '95: Associate Professor, Department Developmental Biology and Department of Medicine
  • July '95 - Present: Professor, Department of Developmental Biology, and Department of Medicine

Advisory Committees

  • 1992-1996: Regular Member, Biochemistry Study Section, Division of Research Grants, NIH
  • 1992-1996: Executive Board Member, Association of Biomolecular Resource Facilities
  • 1992: Grants Review Panel, Missouri Heart Association
  • 1993-1994: President, Association of Biomolecular Resource Facilities
  • 1994-2003: Editorial Board, Letters in Peptide Science
  • 1997-present: Editorial Board, Archives of Biochemistry and Biophysics
  • 1999-present: Editorial Board, Journal of Biomolecular Techniques
  • 2001-2006; 2008-2013; 2014-2019: Editorial Board, Journal of Biological Chemistry