Top
Washington University in St. Louis - School of Medicine
Department of Developmental Biology

Irving Boime, Ph.D.

Professor

Washington University School of Medicine
Campus Box 8103
660 South Euclid Avenue
St. Louis , MO 63110
(314) 362-2556

Links

Research Interests

The placental hormone human chorionic gonadotropin (CG), and the pituitary hormones lutropin (LH), follitropin (FSH), and thyrotropin (TSH) are a family of heterodimeric glycoproteins that share a common alpha subunit but differ in their hormone-specific subunits. One or more of these hormones is essential for gonadal development and maintaining pregnancy and thyroid function. Our laboratory is focused in the following general area:


Structure-function studies. Using site-directed mutagenesis, we are studying the structural determinants that govern the unique post- translational modifications of the related placental and pituitary glycoprotein hormones. These hormones undergo specific modifications and have unique biologic activities. Together with DNA mediated transfection techniques, monoclonal antibody screening, and protein and carbohydrate characterization, we can determine: (a) the region in the hormone associated with unique biologic activity; (b) the region critical for subunit assembly; and (c) disulfide bonds for folding of these hormones and the sequences critical for the differential sorting of the pituitary hormones. Studies are also underway for determining the ligand determinants which are critical for signal transduction in vivo as well as dissecting the structure of the gonadal receptors associated with the biological action of these hormones. Such information has been useful for designing clinically useful agents for treating infertility.  A major focus of the laboratory is elucidating the epitopes that govern the differential sorting of these hormones in unique pituitary secretion pathways.


Selected Publications

 

For a complete list of Dr. Boime's publications, click here

Irving Boime, Ph.D.

Professor

Washington University School of Medicine
Campus Box 8103
660 South Euclid Avenue
St. Louis , MO 63110
(314) 362-2556

Links

Other Information

Training

  • St. Louis College of Pharmacy, St. Louis, MO B.S. 1964 Pharmacology
  • Purdue University, West Lafayette, IN M.S. 1966 Pharmacology
  • Washington University, St. Louis, MO Ph.D. 1970 Pharmacology

Academic Positions

  • Professor, Departments of Pharmacology and Obstetrics/Gynecology, Washington University School of Medicine, 1981 - present
  • Associate Professor, Departments of Pharmacology and Obstetrics/Gynecology, Washington University School of Medicine, 1977 - 1981
  • Assistant Professor, Departments of Pharmacology and Obstetrics/Gynecology, Washington University School of Medicine, 1972 - 1977
  • Postdoctoral Fellow of the American Cancer Society in the laboratory of Dr. Philip

Honors

  • Fellow of the American Cancer Society, 1970 - 1972
  • U.S. Public Health Service, Research Career Development Award, 1977 - 1982

Review Panels

  • Population Research Committee of the NIH, 1991 - present
  • Member of Biochemical Endocrinology Study Section, National Institutes of Health, 1983 - 1987

Editorial Board Memberships

  • Endocrinology (Associate Editor), 1991 -1992
  • Journal of Biological Chemistry, 1981 -1990 & 1993 - present
  • Placenta, 1985 - present