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Washington University in St. Louis - School of Medicine
Department of Developmental Biology

Jeanne Nerbonne, Ph.D.

Alumni Endowed Professor

Washington University School of Medicine
Campus Box 8103
660 South Euclid Avenue
St. Louis , MO 63110
(314) 362-2564

Links

Research Interests

The primary focus of research in this laboratory is the design and execution of experiments aimed at defining the molecular determinants and the physiological roles of the multiple, functionally diverse, types of voltage-gated ion channels expressed in the cardiovascular and nervous systems that underlie action potential generation, propagation and cell-cell communication. Additional studies are focused on defining the molecular mechanisms involved in the physiological regulation of the expression, properties and functioning of these channels and determining how these mechanisms go awry in inherited and acquired diseases of the cardiovascular and nervous systems. 


Accumulating evidence suggests that native neuronal and cardiac voltage-gated ion channels function in macromolecular protein complexes, comprising pore-forming () subunits and a variety of cytosolic and transmembrane accessory and regulatory proteins that influence channel expression and functioning. Although previous studies conducted in heterologous cells have shown that accessory/regulatory proteins influence channel stability, trafficking, localization and/or biophysical properties, the physiological roles of these proteins in the generation of native voltage-gated ion channels in cardiac and neuronal cells are poorly understood. To address these questions directly, we are using in vivo and in vitro molecular genetics strategies to manipulate channel subunit expression, together with electrophysiological, molecular, biochemical and immunohistochemical methods to assess the functional consequences of these manipulations directly and to define the underlying regulatory mechanisms.

Selected Publications

 

For a complete list of Dr. Nerbonne's publications, click here

Jeanne Nerbonne, Ph.D.

Alumni Endowed Professor

Washington University School of Medicine
Campus Box 8103
660 South Euclid Avenue
St. Louis , MO 63110
(314) 362-2564

Links

Other Information

Education

  • 1974 B.Sc., Chemistry, Framingham State College, Framingham, MA
  • 1978 Ph.D., Organic Chemistry, Georgetown University, Washington, DC

Professional Experience

  • 2002- present Alumni Endowed Professor, Department of Molecular Biology & Pharmacology, Washington University School of Medicine, St. Louis, MO
  • 1997 - 2001 Professor, Department of Molecular Biology & Pharmacology, Washington University School of Medicine, St. Louis, MO
  • 1991 - 1996 Associate Professor, Department of Molecular Biology & Pharmacology, Washington University School of Medicine, St. Louis, MO
  • 1985 - 1990 Assistant Professor, Department of Pharmacology, Washington University School of Medicine, St. Louis, MO

Honors and Awards:

  • 2002-present Alumni endowed Professor of Molecular Biology and Pharmacology
  • 1984-1989 American Heart Association Established Investigator Award
  • 1981-1983 American Heart Association Postdoctoral Fellowship Award
  • 1979-1981 National Institutes of Health Postdoctoral Fellowship Award
  • 1979 W. W. Zorbach Memorial Prize for the Outstanding Chemistry Ph.D. Dissertation, Georgetown University, Washington, D.C.

Professional Affiliations:

  • American Association for the Advancement of Science
  • American Physiological Society
  • Society of General Physiologists
  • Society for Neuroscience

Editorial Service:

  • Associate Editor, Journal of Neuroscience
  • 1998 - present Editorial Board, Journal of Molecular and Cellular Cardiology
  • 1995 - 1998 Editorial Board, American Journal of Physiology
  • 1995 - present Editorial Board, Circulation Research
  • 1995 - present Editorial Board, Journal of General Physiology