Washington University in St. Louis - School of Medicine
Department of Developmental Biology

Kelly Monk, Ph.D.

Associate Professor

Washington University School of Medicine
Campus Box 8103
660 South Euclid Avenue
St. Louis , MO 63110
(314) 362-3825

Links

Research Interests

The myelin sheath surrounding axons is one of the most exquisite examples of a specialized cell-cell interaction in the vertebrate nervous system. Myelin is formed by glial cells called oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. These cells associate with axons, and elaborate massive amounts of cytoplasm, ultimately wrapping axons to form the myelin sheath. While progress has been made to determine how glial cells make myelin, there is still much we do not understand.

How do glial cells transition from simple axonal ensheathment to membrane spiraling? What are the signals between glial cells and axons that regulate myelination? How is myelin maintained once it is formed? When myelin regenerates in disease or after injury, do the same developmental pathways that regulate myelination regulate remyelination? Or are there additional pathways necessary for this process, specific to adult tissue?

We use mouse and zebrafish models to better understand how myelinated axons are formed, maintained, and regenerated.

Selected Publications

 

For a complete list of Dr. Monk's publications, click here

Kelly Monk, Ph.D.

Associate Professor

Washington University School of Medicine
Campus Box 8103
660 South Euclid Avenue
St. Louis , MO 63110
(314) 362-3825

Links

Other Information

Education and Professional Experience

  • Associate Professor, Department of Developmental Biology, Washington University School of Medicine, 2016.
  • Assistant Professor, Department of Developmental Biology, Washington University School of Medicine, 2011.
  • Postdoctoral Fellow, Department of Developmental Biology, Stanford University School of Medicine, 2006-2010. Mentor: William Talbot.
  • Ph.D., Department of Cell Biology Neurobiology and Anatomy, University of Cincinnati/Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, 2001-2006. Mentor: Nancy Ratner.
  • B.S. in Biochemistry, Elmira College, Elmira, NY, 1997-2001.

Honors and Awards

  • 2015 Washington University Outstanding Faculty Mentor Award
  • 2012 NIH Bridging Interdisciplinary Research Careers in Women’s Health (BIRCWH) Scholar Award
  • 2006-2009 National Multiple Sclerosis Society Postdoctoral Fellowship