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Washington University in St. Louis - School of Medicine
Department of Developmental Biology

Stacey Rentschler, M.D., Ph.D.

Assistant Professor

Washington University School of Medicine
660 S. Euclid Avenue/Campus Box 8103
Saint Louis , MO 63110
314-362-6212

Links

Research Interests

Developmental Programming and Reprogramming of Conduction Tissue

The cardiac conduction system arises from lineage specification of cardiomyocyte progenitors and functions to generate and propagate electrical impulses within the heart.  Our laboratory is seeking to identify the signaling pathways that instruct cardiomyocytes to become conduction cells during normal development.  In addition, we have demonstrated that activation of the Notch signaling pathways at later stages of maturation can reprogram differentiated cardiomyocytes into conduction-like cells.  Deciphering the signals that instruct cells to adopt a conduction phenotype may ultimately provide insight into regenerative approaches, such as the development of a biologic pacemaker. 

 

Molecular Basis of Congenital Heart Defects

Congenital heart defects, including those that give rise to conduction disorders, are a significant cause of morbidity and mortality.  Wolff-Parkinson-White (WPW) syndrome affects 1 in 500 people and is characterized by accessory atrioventricular pathways in the heart which bypass the normal conduction system and can result in ventricular preexcitation, palpitations, and sudden cardiac death.  Our laboratory uses novel genetically modified mouse models to study the developmental processes that go awry and produce functional ectopic myocardial tissue. 

Selected Publications

 

For a complete list of Dr. Rentschler's publications, click here


 

Stacey Rentschler, M.D., Ph.D.

Assistant Professor

Washington University School of Medicine
660 S. Euclid Avenue/Campus Box 8103
Saint Louis , MO 63110
314-362-6212

Links

Other Information

Education

  • 9/1991 - 5/1995 B.S. Lehigh University (Biochemistry)
  • 8/1997 - 5/2002 Ph.D. Mount Sinai School of Medicine (BiologicalSciences)
  • 8/1995 - 5/2004 M.D. Mount Sinai School of Medicine
  • 6/2004 – 6/2005 Intern in Internal Medicine, Hospital of University of Pennsylvania, Philadelphia, PA
  • 6/2005 – 6/2006 Resident in Internal Medicine, Hospital of University of Pennsylvania, Philadelphia, PA
  • 7/2006 – 6/2011 Fellow, Cardiovascular Disease, Department of Medicine Hospital of University of Pennsylvania, Philadelphia, PA

Academic Positions

  • 7/2011 – 8/2012 Instructor, Department of Medicine University of Pennsylvania, Philadelphia, PA
  • 9/2012 – present  Assistant Professor, Dept. of Medicine and Developmental Biology Washington University School of Medicine
     

Honors and Awards

Lehigh University

  • 1992 Freshman Chemistry Award
  • 1992 Phi Eta Sigma
  • 1994  Alpha A. Diefenderfer Award in Chemistry
  • 1994  Undergraduate Award in Analytical Chemistry
  • 1994  Alpha Epsilon Delta
  • 1994  Phi Beta Kappa
  • 1995  Ullmann Prize in Chemistry
  • 1995  American Institute of Chemists Foundation Award
  • 1995  Graduation with Highest Honors

Mount Sinai School of Medicine

  • 2000 American Heart Association Councils Travel Award Winner
  • 2001 Graduate School of Biological Sciences Award for Academic Excellence
  • 2003  Graduate School of Biological Sciences Doctoral Dissertation Award
  • 2003 Alpha Omega Alpha Honor Society
  • 2004 Barry Coller Award for Excellence in Clinical Medicine
  • 2004 AMWA’s Glasgow-Rubin Achievement Award

Hospital of the University of Pennsylvania

  • 2004 The William Osler Society of Fellows in Medicine
  • 2009  Department of Medicine Measey Senior Research Fellow
  • 2010 Department of Medicine Bradley Award for Bench Research
  • 2011 Keystone Symposium Travel Award
  • 2011 Keystone Symposium Graduate Student/Postdoc Research Competition Winner
  • 2011  Burroughs Wellcome Foundation Career Award for Medical Scientists
  • 2011  Department of Medicine Bradley Award for Bench Research
  • 2012  Keystone Symposium Travel Award

Washington University in St. Louis

  • 2012 Northwestern Cardiovascular Young Investigators’ Forum Second Place Finalist