Faculty members in the Department of Developmental Biology employ several animal model systems, including fruit fly (D. melanogaster), nematode (C. elegans), zebrafish (D. rerio), and mouse (M. musculus) as well as tissue culture systems and embryonic stem cells. By combining experimental advantages of these animal and tissue culture models, along with the knowledge from human genetic and genomic studies in several Departments at WUSM, we can effectively address key questions about human development, physiology, birth defects, disease, and aging.
Engineering cell identity: establishing new gene regulatory and chromatin landscapes. Guo C, Morris SA. Curr Opin Genet Dev. 2017 Jun 28;46:50-57.
Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson…