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Washington University in St. Louis - School of Medicine
Department of Developmental Biology

Human Cells

Kris Kroll, Ph.D.

Jeanne Nerbonne, Ph.D.

Lila Solnica-Krezel, Ph.D.

Andrew Yoo, Ph.D.

 

Recent technical breakthroughs in engineering human somatic cells to induce pluripotent stem cells or directly convert into another cell type offer unprecedented opportunities for regenerative medicine.  These relatively novel research tools, commonly referred to as cell fate reprogramming, allow derivation of individual-specific stem cells or differentiated cell types geared towards developing disease models of inherited diseases or cell replacement-based therapeutic approaches.  Additionally, human embryonic stem cell lines that have been approved as experimental tools can be used to study genetic pathways underlying cellular differentiations.  Towards these goals, faculties in the department use human cells to study genetic pathways that govern cellular differentiation, develop experimental protocols for deriving various cell types for disease modeling or functional rescue of cellular functions lost in diseased states.  

Upcoming Events

Apr 23

Mary Baylies, Ph.D.

Department of Developmental Biology Seminar Series

Sloan Kettering Institute 12:00 pm, Needleman Library

Apr 25

TBD

Development and Regenerative Biology / Cell-Cell Interactions in Cancer Research Forum (Wednesday)

May 2

TBD

Development and Regenerative Biology / Cell-Cell Interactions in Cancer Research Forum (Wednesday)

See all upcoming events

Faculty News

  • Dr. Helen McNeill’s January 2018 Publication

    Congratulations to Dr. Helen McNeill's Lab on their recent publication! Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion. Hoshi M, Reginensi A, Joens…

  • Dr. Kristen Kroll’s December 2018 Publication

    Congratulations Dr. Kristen Kroll's Lab on their new publication. Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in…

See all faculty news