Recent technical breakthroughs in engineering human somatic cells to induce pluripotent stem cells or directly convert into another cell type offer unprecedented opportunities for regenerative medicine. These relatively novel research tools, commonly referred to as cell fate reprogramming, allow derivation of individual-specific stem cells or differentiated cell types geared towards developing disease models of inherited diseases or cell replacement-based therapeutic approaches. Additionally, human embryonic stem cell lines that have been approved as experimental tools can be used to study genetic pathways underlying cellular differentiations. Towards these goals, faculties in the department use human cells to study genetic pathways that govern cellular differentiation, develop experimental protocols for deriving various cell types for disease modeling or functional rescue of cellular functions lost in diseased states.
FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms. BonDurant LD, Ameka M, Naber MC, Markan KR, Idiga SO, Acevedo MR, Walsh SA, Ornitz DM, Potthoff…
Nerve stepping stone has minimal impact in aiding regeneration across long acellular nerve allografts. Yan Y, Hunter DA, Schellhardt L, Ee X, Snyder-Warwick AK, Moore…