Research Interests: (Under Construction)

Biosketch:

Education

• 1985 Magister (M.Sc.) in Molecular Biology (Highest Honors), Warsaw University, Warsaw, Poland
  
• 1991 Ph.D. in Oncology, University of Wisconsin-Madison, McArdle Laboratory for Cancer Research

Research and Professional Experience

• 1984-1985 Undergraduate Research: In the laboratory of Professor Kazimierz Toczko, Warsaw University, Warsaw, Poland Analysis of transcriptionally active chromatin in P. polycephalum.
• October 1984 Summer Research: predoctoral studentship in the laboratory of Professor Andrzej Zagorski, Institute of Biochemistry and Biophysics, Polish Academy of Science, Warsaw Characterization of ribosomal proteins from mitochondria of S. cerevisiae.
• September 1985 Summer Research: predoctoral studentship in the laboratory of Dr. Thomas Schreckenbach, Max-Planck-Institute, Martinsried, Germany Analysis of gene expression during sporulation in P. polycephalum.
• 1985 - 1986 Research Associate: In the laboratory of Professor Kazimierz Toczko, Warsaw University, Warsaw Characterization of nuclear HMG proteins from P. polycephalum.
• 1986 -1991 Ph.D. Research with Dr. William F. Dove, University of Wisconsin, Madison Changes in composition and organization of microtubular structures during the amoebal-plasmodial development in P. polycephalum.
• 1991 - 1995 Postdoctoral Fellow: In the laboratory of Dr. Wolfgang Driever, Massachusetts General Hospital and Harvard Medical School, Boston A genetic screen for mutations affecting zebrafish embryogenesis.
• 1/1996 - 7/2001 Assistant Professor: Department of Molecular Biology, Vanderbilt University
• 8/2001 - 7/2005 Associate Professor: Department of Biological Sciences, Vanderbilt University 8/2005 - 5/2010 Professor: Department of Biological Sciences, Vanderbilt University, Nashville, TN
• 7/2006 - 5/2010 Martha Rivers Ingram Professor of Developmental Genetics: Vanderbilt University, Nashville, TN
• 5/2009 - 5/2010 University Professor, Department of Biological Sciences, Department of Cell and Developmental Biology, and Department of Pediatrics, Vanderbilt University
• 1/2010 - Professor and Head, Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO

Honors and Awards

• 1978, 1979 Champion, National Contest in Biology for High School Students, Poland
• 1985 Magister (M.Sc.) with Highest Honors in Molecular Biology, Warsaw University
• 1986 Distinguished Publication Award, Polish Ministry of Science and Higher Education
• 1989 Wisconsin Power and Light Foundation Fellowship in Cancer Research, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison
• 1997 Basil O’Connor Starter Scholar Award, March of Dimes Birth Defects Foundation
• 1998 Pew Scholar in the Biomedical Sciences, The Pew Charitable Trusts 2005 Distinguished Faculty Member, Vanderbilt University
• 2008 Nominee Mentor of the Year 2008, the VUMC Postdoctoral Association

Selected Publications

Sarmah, S., Barrallo-Gimeno, A. Topczewski, J., Honda, J., Solnica-Krezel, L., and Knapik, E.W. (2010) The secretory cargo adaptor Sec24D is essential for cranial cartilage development. PLoS 1. In press.

Williams, C., Kim, S.H., Ni, T., Mitchell, L., Ro, H., Penn, J.S., Baldwin, S., Solnica-Krezel, L., Zhong, T.P. (2010) Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev. Biol. In press.

Hu, T., Li, C., Van Raay, T.J., Cao, Z., Smith, J.C., Willert, K., Solnica-Krezel, L. Coffey, R. (2010) Myristoylated naked2 antagonizes WNT/β-catenin activity by degrading Dishevelled-1 at the plasma membrane. J. Biol. Chem. In press.

Speirs, C. K., Jernigan, K.K., Kim, S.H., Cha, Y.I., Lin, F., Sepich, D.S., DuBois, R.N., Lee, E., and Solnica-Krezel, L. (2010) Prostaglandin Gβγ signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development 137: 1327-1337

Zeng, X.X.I., *Zheng, X., Xiang, Y., Cho, H.P., Jessen, J.R., Zhong, T.P., Solnica-Krezel, L., Brown, H.A. (2009) Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish. Dev. Biol. 328:363-76. *Contributed equally.

Lin F., Chen, S., Sepich, D.S., Panizzi, J.R., Clendenon, S.G., Marrs, J.A., Hamm, H.E. and Solnica-Krezel, L. (2009) Gα12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. J. Cell Biol. 184:909-21.